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The first class of drugs promotes ferroptosis by inhibiting the Xc-system to reduce intracellular cysteine levels and includes drugs such as Erastin, sulfasalazine, and sorafenib, among which sorafenib is effectively used in the treatment of liver cancer, and its effect can be inhibited by ferroptosis inhibitors [118]

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Clin Chim Acta (2011) 412:103642.10.1016/j.cca.2011.02.021 115 MelnykSFuchsGJSchulzELopezMKahlerSGFussellJJet alMetabolic imbalance associated with methylation dysregulation and oxidative damage in children with autism