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In a series of clinical trials in participants with MCI and AD, nasal application of insulin did improve cognition and glucose uptake in the brain and reduced key biomarkers for AD

Both utilized antibiotic depletion (ABX) to diminish the microecological background, verified therapeutic transferability via fecal microbiota transplantation (FMT), and further achieved partial simulation or restoration of therapeutic phenotypes through butyrate/sodium butyrate supplementation (rescue) ( Level B Support: In the CFA-induced RA rat experiment, the study found that after antibiotic (ABX) treatment, the improvement effect of JFG on foot swelling, synovial lesions and inflammatory factors was significantly weakened

doi: 10.1016/j.ncl.2021.08.001 [PubMed] 35001380 Migdady I, Rosenthal ES, Cock HR

doi: 10.1371/journal.pone.0085387 501 KerrJR