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Under steady-state conditions, the cytoplasmic Keap1 protein binds to Nrf2, inhibiting its activity and maintaining the basal expression of its regulated genes
240 It has also been shown that MTA accumulation and secretion occur in MTAP-deficient GBM, but no significant MTA accumulation was detected in vivo because the stromal cells in the TME express WTAP and consume the MTA emitted by tumor cells and increase the activity of PRMT5
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