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She also notes that setting limits ahead of time can help those who arent willing to completely abstain from alcohol: For example, coming up with a plan for how much theyll drink and over what period of time before they go to a party, rather than in the moment. If you have a celebratory toast in the future, planning ahead is the way to go: Wait at least 24 hours after your last dose For a further reduction in risk, wait 48 hours after your last dose Be aware that the medication reaches steady state (stable blood level) within about five days of regular use Its important to know that due to its prolonged systemic presence and the cumulative sedative effects when combined with alcohol, no specific safe interval can be universally recommended