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In mice, the loss of JNK1 and JNK2 led to more severe age-related OA and ageing of cartilage and synovium (Loeser et al., 2020), an indication that JNK is a detrimental regulator of joint degeneration

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Endurance athletes commonly report improved performance with consistent supplementation, typically requiring 2-3 grams daily for several weeks before benefits appear

In the context of shared mechanistic pathways relevant to thyroidbrain interactions, these data remain biologically informative, yet they also highlight a critical gap in thyroid-specific primary research