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If oxidative stress is highest during specific timessuch as post-exercise, after high mental workload, or during sleepstrategic timing before those periods may offer protective benefit

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A review in JAAOS Global Research & Reviews mapped these peptides across PI3K/Akt, mTOR, TGF-, and AMPK signaling pathways, suggesting their role in musculoskeletal healing (Rahman, Lee & Seeds, JAAOS Global R&R , 2026)