These effects lead to reduced caloric intake as patients consume less food, potentially resulting in lower energy levels
Contraindications also apply to patients with a history of medullary thyroid cancer, multiple endocrine neoplasia syndrome type 2, and hypersensitivity to semaglutide [31]
Gierach M, Gierach J, Skowroska A, et al
As can be seen from the comparison between the example 1 and the comparative example 4, the mixed system of acetonitrile and water is adopted in the example 1 to dissolve the raw materials of N, N-diisopropylethylamine and Arg34GLP-1 (9-37), and meanwhile, the pH is adjusted to 4-6 by acid in the post-treatment, namely, the isoelectric point precipitation is adopted, the purity of the obtained compound 2 is as high as 90% or more, the purity is improved by at least 10% compared with the purity of the compound 4, the complex procedures of removing the organic solvent by rotary evaporation, performing freeze-drying and the like in the prior art are omitted, and the cost can be greatly reduced
