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The glutamatergic hypothesis is also supported by metabolomic studies in related conditions, such as hypertension with tinnitus symptoms, which identify perturbations in alanine, aspartate, and glutamate metabolism pathways (Jialiken et al., 2025)

All support connective tissues , but type I/III are most relevant to facial skin

Peptides are short chains of amino acids that act as signaling molecules, helping direct everyday processes such as repair, metabolism, and energy