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Figure 1 Cytochrome P450-Mediated Metabolic Activation APAP metabolic activation is mainly catalyzed by the cytochrome P450 enzyme and the reactive metabolite associated with hepatotoxicity is commonly considered to be NAPQI (Dahlin et al., 1984)

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Hypoxia-inducible factors (HIF) -2 signaling pathway HIFs participate in the physiological activities of various cells under both hypoxic and normoxic conditions

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