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This phenomenon is well-documented in people who lose weight through any means, whether dietary modification, increased physical activity, bariatric surgery, or pharmacotherapy

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[DOI] [PMC free article] [PubMed] [Google Scholar] 446.Yang C, Merlin D

Meanwhile, it inhibits the phosphorylation of MAPK1 (ERK1/2) to block the proliferation of PASMCs, downregulates NOX4 to reduce ROS production for alleviating oxidative stress, and improves right ventricular fibrosis and energy metabolism by regulating the TGF-1/Bcl-2-Bax axis (Luo et al., 2021