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Clinical Development Program of Lixisenatide Phase II Dose-Finding Study The doseresponse effect of lixisenatide was evaluated in a large group ( n = 542) of metformin-treated patients with type 2 diabetes using OD or twice-daily (BD) lixisenatide regimens (530 g OD or BD) [10]

[16] Adverse GI effects reported during triamterene and/or hydrochlorothiazide therapy include abdominal pain, anorexia, appetite disturbance, dysgeusia, gastric irritation, cramps, constipation, nausea, vomiting, sialadenitis, xerostomia (dry mouth), and diarrhea

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This is crucial for the repair of bone fractures and maintaining bone health in general