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Vitamin C has protective effects against liver oxidative damage, particularly when used in combination with glutathione

Beyond its antioxidant role, selenium also supports thyroid hormone synthesis and mitochondrial function, two processes that are commonly disrupted in PCOS

One study suggests that the decrease in vagal signaling seen with HFD feeding is due to upregulation of K+ channels in the nodose ganglia, increasing hyperpolarization of VANs 67 , while other studies have implicated changes in the gut microbiota as a contributor to vagal afferent desensitization during HFD feeding (see the Gut microbiotabrain connection section)