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Cardiovascular outcomes with ertugliflozin in type 2 diabetes

Only two loci were associated with elevated serum UA levels (SLC2A9 for lead single nucleotide polymorphism rs7678287 and ABCG2 for lead single nucleotide polymorphism rs2231142)

When NNMT is active, fat cells become metabolically lazy. By blocking it, this peptide reactivates fat cell metabolism, increases NAD+ availability in adipose tissue, and essentially flips a switch from fat-storing to fat-burning at the cellular level