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An international research team including the Institute for Research in Biomedicine (IRB Barcelona) in Spain, the Karolinska Institute in Sweden, and the University of Houston in the United States used animal experiments to show that the protein neuritin 1, expressed in brown fat, increases energy expenditure and thereby suppresses weight gain

In clinical trials, about 1 in 12 people experienced diarrhea regardless of their dose [2]

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Dietary sources include Brazil nuts (which contain exceptionally high selenium concentrations - just 2-3 nuts provide adequate daily selenium), fish and seafood, poultry, eggs, and mushrooms grown in selenium-rich soil