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308,309 Drugs such as imatinib, aspirin, and linagliptin have been shown to decrease inflammation and improve the symptoms of UC by inhibiting the JAK/STAT3 signaling pathway, decreasing inflammatory cell infiltration and promoting intestinal mucosal repair via the regulation of immune responses

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Another consequence of obesity is chronic overactivity of the sympathetic nervous system, which, together with the previously described consequences of chronic obesity, induces hypertension and increases the risk of heart disease, stroke, and chronic kidney dysfunction (2, 6, 7) ( Figure 1 )

Glucagonlike peptide-2 receptor activation in the rat intestinal mucosa