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Kidney & CV Protection 3 FDA-approved to reduce the risk of worsening kidney disease, kidney failure, and cardiovascular death in adults with type 2 diabetes and chronic kidney disease

Tirzepatide is a dual GLP-1 and GIP receptor agonist, which is part of why SURMOUNT-1 participants lost more weight on average than STEP 1 participants lost on semaglutide, though the two trials were not run head-to-head in the same population

A biomarker that has been qualified for a specific context of use can be relied upon to have a specific interpretation (FDA, 2020a,b), thus reducing the uncertainty that is currently involved in interpreting biomarker results from clinical trials

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