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This is because the parameters of intrinsic fluorescence (particularly those of tryptophan (Trp) fluorescence), such as intensity, lifetime, anisotropy, and peak emission wavelength, are highly sensitive to the local environment and provides valuable, label-free insights into protein structure, dynamics, and conformational changes

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The cystic and necrotic characteristics aligned with known patterns of aberrant angiogenesis in metastatic MPNST but also necessitated differentiation from vascular lesions related to infectious etiologies ( The pathological diagnosis of MPNST requires the integration of histomorphology, immunophenotyping, and molecular profiling