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The unprecedented surge in demand meant that all parts of the supply chain were stretched to the limit, to the point where even auto-injector pens were in short supply

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GLP-related compounds are studied for how they influence metabolic signaling

Nissen observes, because studies of these drugs for obesity show that they reduce death due to various other causes. After median treatment of 47.4 months, the six-component cardiorenal end point occurred in 23.7% of tirzepatide-treated patients versus 27.4% of dulaglutide-treated patients, translating to a hazard ratio (HR) of 0.84 (95% CI, 0.79-0.90