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Preclinical studies use the pairing to probe parallel effects on growth-factor signalling, cytoskeletal remodelling, and angiogenic responses in vitro
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Human studies have been limited but suggest good tolerability
For CY 2027 and subsequent updates, we proposed to trend the CY 2025 threshold of $630 forward using the four-quarter moving average PPI levels for Pharmaceuticals for Human Use, Prescription for CY 2025 (third quarter) forward using the PPI for Pharmaceuticals for Human Use, Prescription for the applicable payment year (third quarter) (90 FR 3362324)
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