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Description

3.3 Long-acting GLP1 receptor agonists: Once-weekly 3.3.1 Semaglutide SMG is an analog of long-acting GLP-1, mainly used to control T2DM, and is also suitable for promoting weight loss in people with mild obesity (95, 96)

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Combining similar treatments can intensify side effects, particularly nausea, vomiting, and diarrhoea

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Tirzepatide (Mounjaro, Zepbound) Tirzepatide adds GIP receptor activation to GLP-1 agonism, creating a dual mechanism that achieves approximately 21% weight loss in trials

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