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Member of the Latinoamerican Board of Eli Lilly and Sanofi Aventis Member of the National Board of the following laboratories: Novo Nordisk, Novartis, GlaxoSmithKlein Sanofi, Aventis, Boheringer Ingelheim, Bristol Myers, Astra Zeneca Main investigator of Protocols from: Eli Lilly, Novo Nordisk, Novartis, GlaxoSmithKlein, Takeda, PPDF, Pfizer, Merck Sharp Dome, Amgen, Roche, Minimed, Quintiles Speakers of the former laboratories

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Risk of bias at the study were performed for each outcome (and, where relevant, at specific time points) with respect to the effect of assignment to the intervention (i.e., an intention-to-treat effect)

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