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ICV IgG1-treated mice maintained stable body weight, while all doses of ICV mGIPR-Ab/P3 led to substantial weight loss (Extended Data Fig

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Lillys Zepbound, approved in November 2023 as the Indiana-based drug giants answer to Novo Nordisks Wegovy, showed 21% average weight loss after 72 weeks for its highest dose in its Phase 3 trial, and a mid-stage study of another Lilly experimental medicine, called retatrutide, showed 24% weight loss after just 48 weeks

Once mixed correctly, the solution can be measured accurately using a suitable syringe