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PMID: 18074684 Nishikawa M, Milhorat TH, Bolognese PA, McDo NB

With a rapidly increasing number of GLP-1 drugs already being prescribed for conditions such as type 2 diabetes, obesity and kidney disease, these results suggest these medications could potentially be repurposed to reduce the risk of no-reflow in heart attack patients

The same improved glucose tolerance with increased GLP-1 and leptin levels was found in DPP4-depleted Dark Agouti rats with diet-induced obesity (46)

Consistent with our previous findings (20), oral gavage of systemically active doses of sitagliptin (10 mg/kg) inhibited plasma DPP-4 activity by approximately 85% when assessed 30 minutes after oral administration (Figure 1B)