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Retatrutide additionally shows a dose-dependent increase in heart rate, attributed to its glucagon-receptor activity, and indirect network meta-analyses flag the highest adverse-event burden among the modern agents for the most potent drugs

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Participants with normal renal function were eligible for inclusion if they were judged to be of general good health by the investigator, on the basis of a medical examination (including physical examination, medical history, vital signs and electrocardiogram [ECG]) with laboratory parameters within normal limits

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