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To study the permeability of nanoparticles in vitro BBB models, which conform to the 3R principles with the minimalization the number of animal experiments, are widely used either in static [34] or in dynamic conditions by employing lab-on-a-chip systems [35]

10.1016/j.pnpbp.2020.110148 120 van der WesthuyzenJ.Fernandes-CostaF.MetzJ

An eight-week open-label trial involving children aged 313 years with autism revealed that oral lipoceutical glutathione supplementation resulted in significant increases in plasma-reduced glutathione levels