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Comment: Several commenters requested, as an alternative to our proposal to replace the estimated allowed amount with the median allowed amount and to add the 10th and 90th percentile allowed amounts, that CMS require hospitals, without exception, to make public all their payer-specific negotiated charges in dollars and cents, thus eliminating the need for the currently required estimated allowed amount or the proposed median, 10th percentile, and 90th percentile allowed amounts

That said, like any medical treatment, there are important considerations to keep in mind

As a protease inhibitor, A2M reduces inflammation in arthritic joints and helps to deactivate a variety of proteinases that typically degrade joint cartilage