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Common in-vitro readouts include scratch-wound migration assays and angiogenesis tube-formation assays, alongside investigations of fibroblast behavior and nitric-oxide and growth-factor pathways

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Drugs.com, May 2026) SEMALEAN Found Function Improved Even as Lean Mass Dipped The SEMALEAN trial produced one of the more reassuring findings in this area: lean mass declined initially then stabilised , while handgrip strength improved by 4.5 kg and sarcopenic obesity prevalence fell from 49% to 33% over twelve months

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