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More specifically, orforglipron is a potent partial GLP-1 RA which is biased towards G-protein activation over to -arrestin recruitment at the GLP-1 receptor [23]

Considering the physiological role of selenoproteins in antioxidation and the detrimental effects of oxidative stress in chondrocytes, aberrant selenium metabolism is likely to disrupt cartilage homeostasis and cause arthropathic diseases via dysregulation of redox homeostasis (Fig

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