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While the regulation of MTHFR activity is closely controlled by SAM at C-terminal regulatory domain, more studies indicated that the human MTHFR enzyme activity is also regulated by multiple phosphorylated sites on a serine-rich N-terminal extension region 20

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Calls A, TorresEspin A, Tormo M, MartnezEscard L, Bonet N, Casals F, Navarro X, Yuste VJ, Udina E, Bruna J (2022) A transient inflammatory response contributes to oxaliplatin neurotoxicity in mice