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Discussion In the present study, we observed that non-selective inhibition of cytochrome P450 strongly enhanced the hepatotoxicity and nephrotoxicity of OTA

Paul Talalay and researchers at Johns Hopkins University linked these findings (Prochaska et al., 1992) and identified sulforaphane, isolated from broccoli, as a potent inducer of phase II detoxification enzymes including glutathione-S-transferase (GST) and NAD(P)H oxidoreductase 1 (NQO1) (Zhang et al., 1992)

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