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ADP/O: Ratio of ADP molecules phosphorylated to oxygen atoms reduced, reflecting phosphorylation efficiency

At 40 weeks, all three doses (3 mg, 12 mg, 36 mg) of orforglipron achieved the primary endpoint of superior A1C reduction compared to placebo , lowering A1C by 1.3% to 1.6% from a baseline of 8.0% , with improvements seen as early as 4 weeks