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[3] Persulfides are intermediates in the biosynthesis of iron-sulfur proteins [4] and are invoked as precursors to hydrogen sulfide, a biological signaling molecule

A possible explanation is that DPP-IV inhibition could not raise the GLP-1 levels sufficiently to therapeutic range when the basal GLP-1 level was too low to begin with ( The differences in the magnitude of treatment responses to linagliptin between the high and low GLP-1 levels was more pronounced in T2D than prediabetes