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The experimental trail included a 26-week treatment period, a dose-escalation period of up to 6 weeks, and a 6-week follow-up period after the end of treatment

Given that M-cells have well-accepted BT capability and overlie intestinal lymphoid aggregates, M-cell mediated BT is one plausible mechanistic explanation [16, 17]

CS challenge stimulated the reduction of T-AOC and GSH in lung tissue, while high dosage of GHK-Cu pretreatment relieved the decrease of these expression levels in lung tissue