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It is imperative to visually evaluate the docking poses and consider other factors, such as the strength and type of chemical interactions between the protein and ligand, the conformational stability of the complex, and the biological relevance of the docking pose

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This increase in WBC (of approximately 200 cells/microL vs placebo, in four pooled placebo-controlled clinical studies, with a mean baseline WBC count of approximately 6600 cells/microL) is not considered to be clinically relevant

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