What to Expect: Benefits, Side Effects & Monitoring Benefits my patients commonly report Steady, predictable weight loss (often 12 lbs per week after the initial titration) Improved energy and reduced joint pain Better blood pressure, cholesterol, and blood-sugar control Decreased risk of cardiovascular events (supported by large outcome trials) Renewed confidence and improved quality of life Common side effects (usually mild and improve within 48 weeks) Nausea, vomiting, diarrhea, or constipation Temporary fatigue Heartburn or burping Serious side effects are rare but possible (e.g., gallbladder issues, pancreatitis)
4), with no difference by sex (effect size 0.05, 95% CI 0.03 to 0.07 in men
Semaglutide is the active ingredient in an oral pill called Rybelsus, weekly injections sold as brand names Wegovy and Ozempic, and as compounded versions of the injection or oral tablet
During the neuroinflammatory process, microglia get over-activated and oversensitive, and they can trigger the release of several cytotoxic molecules like tumor necrosis factor (TNF), pro-inflammatory cytokines (e.g., IL-1, IL-6, IL-18), and interferon- (IFN-), and oxidative metabolites (e.g., reactive nitrogen and oxygen species, and nitric oxide) [13]
