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This self-inhibition at high doses diminishes degradation efficiency, confounds the dose-response relationship, and complicates efficacy predictions, while potentially elevating the risk of systemic side effects (Fig

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Thiazolidinediones (TZDs): Enhance peripheral insulin sensitivity

Phase II Detoxification: It is a key substrate for the enzyme Glutathione S-transferase (GST), which binds to toxins and xenobiotics (foreign chemical substances), rendering them water-soluble for excretion