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As not all patients with fatty livers develop NASH, some individuals must possess protective mechanisms to shield them from lipotoxicity, e.g., lipid desaturation and inhibition of lipid-induced inflammation [67]

At that time, Merck was not only interested in the drugs applications for diabetes and weight loss but also recognized its potential for treating non-alcoholic steatohepatitis

Whilst there is no confirmed causal link between retatrutide and serious cardiac events based on current data, the drug's pharmacological profile means that certain symptoms should never be ignored