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599 The interlaminar astrocytes (which populate brains of high primates and are not present in other species 32,33 ) are highly vulnerable to AD pathology: at the advanced stages of the disease interlaminar astrocytes disappear, 600 although how this impacts on the disease pathophysiology remains unknown

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They are most likely to be visible marks of age-related degenerative changes which are worsened by solar oxidative stress.(3) White spots represent areas where skin cells are no longer protected by melanin from the harmful effects of the sun