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Though conventional wisdom and anecdotal evidence says that this property is helpful for dark under-eye circles and puffy eyes , we have to mention that the double-blind research we have found about a 3% caffeine gel concluded that " the overall efficacy of the selected caffeine gel in reducing puffy eyes was not significantly different from that of its gel base ." But you know, the proof is in the pudding

While this work showed promise, more recent investigations showed that ascorbate does not prevent human ARN cataract formation when consumed as a dietary supplement (170, 171)

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213 Instead, inhibition of the H 2 S-synthesising trans-sulphuration pathway enzymes CBS and CSE, together with 3-MST, still holds great promise for cancer treatment, 81,143,214 as outlined below