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It upregulates genes involved in collagen synthesis (COL1A1, COL3A1, COL5A1), extracellular matrix remodeling (decorin, fibromodulin), and antioxidant defense (superoxide dismutase, glutathione peroxidase) while simultaneously suppressing genes associated with inflammation (IL-6, TNF-alpha), fibrinogen production, and tissue destruction (several MMPs)

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FIGURE 1 The studies included in the qualitative synthesis (Table 2) (Yamane et al., 1995

2- Vary the injection site If you receive vitamin B12 injections often, then its important not to use the same location on the body as your injection site two times in a row