The NO pathway is especially important in endothelial cells, as PKA activates NO synthase (NOS), which can produce more nitric acid and does result in reduced small intestine, large intestine, and colon motility
A recent investigation reported that patients taking the weight loss drug Ozempic, along with others such as Wegovy, Mounjaro, Rybelsus, Trulicity, and Saxenda, could experience painful side effectssymptomatic of a condition known as gastroparesis, or stomach paralysis
Those with both type 2 diabetes/obesity and rheumatoid arthritis who are considering GLP-1 therapy should discuss this with both their GP and rheumatologist
This aligns with observations made when the GLP-1 albumin fusions were cleaved at the C-terminal end upon exposure to CPA