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This leads to symptoms such as joint pain, stiffness, warmth, redness, and limited mobility, which can significantly impact the quality of patients life [2]

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Another contributing factor for erythroblasts maturation is the presence of growth differentiation factor 11 (GDF11) and 15 (GDF15), which belong to the transforming growth factor- (TGF-) superfamily and influence erythroid maturity by modulating the Smad2/3 signaling pathway