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2 The discovery of ferroptosis The concept of ferroptosis was formally proposed by Dixon in 2012 ( 3 Ferroptosis regulation mechanism Ferroptosis is a controlled iron-dependent lipid peroxidation cell death controlled by many metabolic pathways, such as redox reactions, iron homeostasis, glutathione metabolism and lipids ( Figure 1 )

The reduction in IgE levels was confirmed in myeloma B cells, U266 (Fig

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