15 Conclusion and future directions As outlined in this paper and Supplementary Table S1, there is evidence supporting the hypothesis that certain natural compounds, such as flavonoids, have antidepressant properties

Maintaining optimal levels of glutathione appears to be important for supporting cognitive function, especially as we age.* The normal process of aging is associated with a decrease in glutathione regulation, which can result in increased oxidative activity.* Less than optimum levels of glutathione are observed in individuals experiencing a decline in cognitive function.* Conversely, individuals living over 100 years tend to have higher glutathione reductase activity.* A common mistaken belief is that glutathione is not well absorbed when its taken orally, but significant data confirms it is efficiently absorbed across the intestinal epithelium by a specific uptake system.* Glutathione-SR from Thorne Research represents an important breakthrough in glutathione supplementation

Acta Physiol Pharmacol Ther Latinoam 46(2):5769 Arisawa S, Ishida K, Kameyama N, Ueyama J, Hattori A, Tatsumi Y, Hayashi H, Yano M, Hayashi K, Katano Y, Goto H, Takagi K, Wakusawa S (2009) Ursodeoxycholic acid induces glutathione synthesis through activation of PI3K/Akt pathway in HepG2 cells
Can glutathione keep you awake at night