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Thus, while we were not successful in obtaining more reactive analogs at this point, this approach allows us to explain the observed low reactivity at physiological pH and offers a valuable tool for guiding the future design of nucleotide-based inhibitors with optimized preorientation and reactivity profiles, providing a systematic framework for enhancing these compounds reactivities in a targeted manner

Dietary Therapies (Ketogenic, Atkins, etc.) Rationale : Previous studies have demonstrated the safety and efficacy of the Modified Atkins Diet (MAD) in attenuating seizures in patients with intractable epilepsy

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