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Emerging Role of GLP-1 Agonists in Obesity: A Comprehensive Review of Randomised Controlled Trials

These include: Nausea (the most frequently reported adverse effect) Vomiting Diarrhoea Constipation Decreased appetite (which, while contributing to weight loss, can occasionally be excessive) These effects were generally mild to moderate in severity and occurred most frequently during the dose-escalation phase

It represents a fundamentally different pharmacological strategy, one that early clinical data suggests could nearly double the weight loss seen with semaglutide while simultaneously delivering dramatic improvements in liver fat, metabolic markers, and body composition