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Transl Psychiatry 8, 242 (2018)

You can tell your muscle is fatigued if it quivers or the force behind the movement becomes weaker, Lookabaugh-Deur notes

Severe, persistent vomiting that prevents adequate fluid intake, intense abdominal pain, or signs of gastroparesis (severe gastric retention) warrant medical evaluation

Glutamate/GABA/glutamine ratios in intact and ischemia reperfusion challenged rat brain subregions, the effect of ischemic preconditioning