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Microsomal prostaglandin E synthase-2 is not essential for in vivo prostaglandin E2 biosynthesis

Created under a sharply different political landscape, the 2026 Final Rule departs from the Proposed Rule of November 26, 2024 (2026 Proposed Rule) in a number of ways

Furthermore, it promotes the polarization of microglia from the pro-inflammatory M1 phenotype (indicated by a decrease in the CD86 + ratio) to the anti-inflammatory M2 phenotype (indicated by an increase in the CD206 + ratio)

The underlying cause of these observations are likely to be multi-factorial, receiving contributions from metabolic, inflammatory, and vascular factors