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Thyroid (2018) 28:78098

They can be worse in the morning or when lying down and may worsen with straining, coughing, or bending

[DOI] [PMC free article] [PubMed] [Google Scholar] 69.Fearon K, Strasser F, Anker SD, Bosaeus I, Bruera E, Fainsinger RL, Jatoi A, Loprinzi C, MacDonald N, Mantovani G, Davis M, Muscaritoli M, Ottery F, Radbruch L, Ravasco P, Walsh D, Wilcock A, Kaasa S, Baracos VE

After 12 weeks on the maximum dose, the medicine should be discontinued if the patient has not lost at least 5% of their weight