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Nasal sprays contain active pharmaceutical ingredients, for either systemic or local effects, in the form of a solution or suspension with excipients (e.g., preservatives, buffering agents, viscosity modifiers, emulsifiers), filled in non-pressurized dispensers that deliver a spray containing a metered dose of the drug

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After that 30-day window, the potency of the solution may begin to decline even under ideal refrigeration conditions